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Hydrochloride is a chemical term; it is an acid salt formed when hydrochloric acid reacts with an organic base. These salts are often used to make tablets. Some medicines require the addition of salts as an adjuvant in order to dissolve in the stomach or to enter the bloodstream. One of the purposes of salts is to stabilize medicines. This gives medicines a longer shelf life. More than 50% of all existing medicines are available as salts. Hydrochloride is the most commonly used salt and 15.5% of all medicines contain hydrochloride. All oxycodone is the hydrochloride salt, but sometimes the drug data information may shorten the name to just oxycodone. However, oxycodone hydrochloride and oxycodone are the same medicine. There are some medicines, for example metoprolol, that have two different salts (in this example metoprolol tartrate and metoprolol succinate). If a medicine has two different salts, they are usually not interchangeable. The choice of salt depends primarily on the pH of the medicine (that is, how acidic or alkaline it is). Other factors that influence the choice of salt include the natural stability of the medicine, the intended use, how it will be administered and the intended dosage form.
Salts may also be added during the manufacture of a controlled-release form to improve a drug’s taste, efficacy, make it less painful if it is to be injected, or extend its patent life.

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